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    • The genome sequence of the fish pathogen Aliivibrio salmonicida strain LFI1238 shows extensive evidence of gene decay 

      Hjerde, Erik; Holden, Matthew TG; Seeger, Kathy; Lorentzen, Marit Sjo; Bason, Nathalie; Paulsen, Steinar; Willassen, Nils Peder; Churcher, Carol; Harris, David; Norbertczak, Halina; Quail, Michael A; Sanders, Suzanne; Thurston, Scott; Parkhill, Julian; Thomson, Nicholas R (Journal article; Tidsskriftartikkel; Peer reviewed, 2008-12-19)
      <b>Background:</b> The fish pathogen Aliivibrio salmonicida is the causative agent of cold-water vibriosis in marine aquaculture. The Gram-negative bacterium causes tissue degradation, hemolysis and sepsis in vivo.<BR><BR> <b>Results:</b> In total, 4 286 protein coding sequences were identified, and the 4.6 Mb genome of A. salmonicida has a six partite architecture with two chromosomes and four ...

    • Human oxygen sensing may have origins in prokaryotic elongation factor Tu prolyl-hydroxylation 

      Paulsen, Steinar (Journal article; Tidsskriftartikkel; Peer reviewed, 2014-09-02)
      The roles of 2-oxoglutarate (2OG)-dependent prolyl-hydroxylases in eukaryotes include collagen stabilization, hypoxia sensing, and translational regulation. The hypoxia-inducible factor (HIF) sensing system is conserved in animals, but not in other organisms. However, bioinformatics imply that 2OG-dependent prolyl-hydroxylases (PHDs) homologous to those acting as sensing components for the HIF system ...